TOPOLOGY OF EVOLVING, MUTAGENIZED VIRAL POPULATIONS: QUASISPECIES EXPANSION, COMPRESSION, AND OPERATION OF NEGATIVE SELECTION

Topology of evolving, mutagenized viral populations: quasispecies expansion, compression, and operation of negative selection

Abstract Background The molecular events and evolutionary forces underlying lethal mutagenesis of virus (or virus extinction through an excess of mutations) are not well understood.Here we apply for the first time phylogenetic methods and Partition Analysis of Quasispecies (PAQ) to monitor genetic distances and intra-population structures of mutant

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Rapid and persistent selection of the K103N mutation as a majority quasispecies in a HIV1-patient exposed to efavirenz for three weeks: a case report and review of the literature

Abstract Introduction Selection of the K103N mutation is associated with moderately reduced in vitro fitness of HIV.Strains bearing K103N in vivo tend to persist, even in the absence of additional drug pressure, as minority quasispecies, often undetectable in genotyping resistance testing assays, performed at standard conditions.Here, we report on

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Workshop for priority-setting in Aedes aegypti control interventions in Latin America and the Caribbean: a policy dialogue

This article presents the results of a dialogue between decision-makers and experts in Latin America and the Caribbean on priority-setting for interventions and studies on Aedes aegypti control.The article is part of a project that included a systematic review of mosquito control strategies and a qualitative study with key informants from the regio

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